Study of LIF polymorphisms and phenotypes of CAKUT in a Brazilian pediatric population
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https://doi.org/10.53660/CONJ-1100-R17Palavras-chave:
Congenital anomalies of the urinary tract (CAKUT), LIF, Gene candidate, Association studiesResumo
The congenital anomalies of the urinary tract — CAKUT emerge from the interaction between genetic anomalies and environmental factors present before and during pregnancy. The aim of this study was to evaluate possible associations between pathways of gene polymorphism LIF and CAKUT. The study was done with 538 Brazilian volunteers, the control group being 160 females and 102 males, totaling 262 healthy individuals. The case group contained 115 females and 161 males, totaling 276 pediatric patients originated from the CAKUT ambulatory from Federal University of Minas Gerais, Brazil. The rs 737812, 929271 and 737921 of LIF were investigated. In association analyzes between cases and controls, no correlation was seen between the rs 737812 and 929271 of LIF and CAKUT. There was a positive association between rs 737921 and general CAKUT as well as with the various phenotypes studied except of hydronephrosis and of multicystic renal dysplasia. Force of association of rs LIF to general CAKUT is measured by a p-value of 0.0009 after 1000 permutations.
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