IL-10 and TNF-α genes polymorphisms and the development of cervical lesions and cervical adenocarcinoma: a case-control study.
DOI:
https://doi.org/10.53660/CONJ-582-211Palavras-chave:
Tumor Necrosis Factor alpha, Interleukin 10, Cervical lesions, Adenocarcinoma, HPVResumo
Cytokines have an important role in the progression of cervical lesions and/or adenocarcinoma. We investigated whether polymorphisms at the promoter regions of the IL-10 -1082 (A> G, rs1800896) and TNF-α -308 (G>A, rs1800629) genes were associated with susceptibility to progression of cervical dysplasia and adenocarcinoma. The study consisted of 240 women infected with HPV (72 with adenocarcinoma and 168 with cervical intraepithelial lesions), and 169 healthy control women. There was a significant increase in the frequency of the IL10 -1082G allele in both cervical dysplasia (OR = 1.39; P = 0.0372) and adenocarcinoma patients (OR = 2.19; P = 0.0002). For the TNF-α -308 polymorphism, there was higher susceptibility to cervical lesions, in relation to risk factors such as: age > 35 years old (OR = 2.57; p = 0.0057), age of first sexual intercourse 1st < 18 years old (OR = 6.6224, p < 0.0001), smoking (OR = 3.80; P = 0.0003), African ancestry (OR=5.18, p < 0.0001) and co-infection with Chlamydia trachomatis (OR=2.41, p=0.0315). Our findings suggest that polymorphisms in the IL-10 and TNF-α genes may play a role in the susceptibility or severity of cervical disease in the study population.
Keywords: Tumor Necrosis Factor-alpha; Interleukin 10; Cervical lesions; Adenocarcinoma; HPV.
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